96-well plates are commonly used in biological laboratories, which are also called microplates. Microplates are widely used for high-throughput testing and cultivation in the life sciences and chemical analysis industries. Common 96-well plates include PCR plates, high-throughput liquid chromatography with deep well plates, deep well plates for sample storage and enzymes. Standard plates and cell culture plates, the main purpose of the 96-well plate sealer is to prevent evaporation and leakage of various microplates in the detection reaction by heat-sealing various special heat-sealing films. Another function of the sealer is to ensure the safe storage and transportation of samples in the microplate.
Sealing machines are generally divided into two types: manual and automatic. The automatic sealing machine is generally used in large-scale drug screening supporting workstations with a high degree of automation. However, due to the complex structure of the automation equipment, the volume is large and the price is relatively high. The manual sealing machine is relatively low in price and takes up less space. The practical range is wider than the automatic sealing machine: it is mainly used for the long-term cryopreservation of blood samples in the blood center and the gene amplification experiment samples to prevent evaporation; CDC analysis instrument sample storage; public security forensic identification system and DNA workstation gene amplification experiment sample prevention Evaporation; The manufacturer of the microplate kit is sealed by the kit manufacturer, which can assist a large number of research-oriented scientific research units, hospitals and school laboratories to conduct microplate-related experiments.
The main product on the market, the manual sealing machine is the DHS sealing machine commonly used in the market. At present, most blood centers and public security forensic identification systems in the country choose to purchase this product; the automatic sealing machine is a common microplate heat sealing machine produced by Agilent, which is mainly purchased by the drug screening department of a large pharmaceutical company. The manual sealing machine adopts a lever operation design, which can achieve satisfactory results under a small pressure. At the same time, the instrument also has temperature and time adjustable functions, and different adapters can seal various PCR plates and microplates to meet different needs.
The DHS 96-well plate sealing machine simultaneously displays the heat sealing temperature and time (timed by a built-in timer) for easy operation and electronic feedback design to ensure accurate pressure transfer time. Ergonomic design reduces fatigue caused by repeated use. The operation is simple, just open the sealing machine to set the required heat sealing temperature and time. When the film sealer reaches the set temperature, place the sample plate on the appropriate adapter and place the appropriate heat-sealing film on the sample plate. Press the handle of the sealing machine and the timer starts counting. Keep the pressure until the time is over. After the timing is over, the sealing machine beeps, release the handle and complete the heat sealing.
In short, the 96-well plate sealing machine of the present invention solves the traditional rubber sealing film not tightly sealed and easy to leak, and to a certain extent reduces the cost of the sealing plate, and the applicable plate type is also greatly expanded.